Hsp70 (Hsp72) Active Recombinant Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp70 (Hsp72) Active Recombinant Protein  50 µg NSP-555D $300.00  
Hsp70 (Hsp72) Active Recombinant Protein  200 µg NSP-555F $825.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Species Reactivity
not applicable

Applications
AA, WB Control

Format
Human Hsp70 in 1xDPBS (2.7mM KCl, 1.5mM KH2PO4, 137mM NaCl, and 8.1mM Na2HPO4).

Purity
>90% (SDS-PAGE)

Source
Recombinant Hsp70 cloned from a human embryonic cDNA library and expressed in E. coli.

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
Hsp70 (Hsp72) Active Recombinant Protein NSP-555D  
Hsp70 (Hsp72) Active Recombinant Protein NSP-555F  

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Citations
Launch Citation Database

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