Hsp90 Native Human Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp90 Native Human Protein  50 µg SPP-770D $300.00  
Hsp90 Native Human Protein  200 µg SPP-770F $715.00  
Background
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Table of Abbreviations

Abbreviated Name
Hsp90 Native Human Protein

Expression System
Native human Hsp90 purified from HeLa cells

Species Reactivity
not applicable

Applications
WB Control

Purification
Multi-step chromatography

Source
Human

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPP-770_LOT-08010707
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp90 Native Human Protein SPP-770D  
Hsp90 Native Human Protein SPP-770F  

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Citations
Launch Citation Database

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