p70 S6K Recombinant Human Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
p70 S6K Recombinant Human Protein  5 µg PPK-439Z $320.00  
p70 S6K Recombinant Human Protein  1 µg PPK-439X $95.00  
Background
p70 S6K is a mitogen stimulated serine/threonine protein kinase that regulates the cell growth and G1 phase cell cycle progression. p70 S6K is activated by serum stimulation and can be inhibited by both wortmannin and rapamycin. Activation of p70 S6K by multi-site phosphorylation requires phosphoinositide 3-kinase (PI3-K)-dependent signal(s) leading to sequential phosphorylation at two key residues: Thr389 and Thr229. Thr229 phosphorylation is mediated by phosphoinositide-dependent kinase 1 (PDK-1), and is dependent upon prior phosphorylation of Thr389. Multiple residues in the p70 S6K pseudosubstrate domain (e.g. Ser411, Thr421, and Ser424) are also subject to activating phosphorylation by upstream kinases.

Table of Abbreviations

Abbreviated Name
p70 S6K Recomb Human Protein

Expression System
Recombinant active full length human p70S6K expressed by baculovirus in Sf9 insect cells.

Species Reactivity
not applicable

Applications
KA

Purification
>75% pure as determined by SDS-PAGE analysis

Tag

Source
Human

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
p70 S6K Recombinant Human Protein PPK-439Z  
p70 S6K Recombinant Human Protein PPK-439X  

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