p70 S6K Active Recombinant Protein

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
p70 S6K Active Recombinant Protein  5 µg PPK-439Z $320.00  
p70 S6K Active Recombinant Protein  1 µg PPK-439X $98.00  
Background
p70 S6K is a mitogen stimulated serine/threonine protein kinase that regulates the cell growth and G1 phase cell cycle progression. p70 S6K is activated by serum stimulation and can be inhibited by both wortmannin and rapamycin. Activation of p70 S6K by multi-site phosphorylation requires phosphoinositide 3-kinase (PI3-K)-dependent signal(s) leading to sequential phosphorylation at two key residues: Thr389 and Thr229. Thr229 phosphorylation is mediated by phosphoinositide-dependent kinase 1 (PDK-1), and is dependent upon prior phosphorylation of Thr389. Multiple residues in the p70 S6K pseudosubstrate domain (e.g. Ser411, Thr421, and Ser424) are also subject to activating phosphorylation by upstream kinases.

Table of Abbreviations

Expression System
Recombinant active full length human p70S6K expressed by baculovirus in Sf9 insect cells.

Species Reactivity
not applicable

Applications
KA

Purification
>75% pure as determined by SDS-PAGE analysis

Tag

Source
Human

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
p70 S6K Active Recombinant Protein PPK-439Z  
p70 S6K Active Recombinant Protein PPK-439X  

Related Products

Product Name Catalog#
Kemptide Substrate
 		SPK-101J
PDK1 Active Recombinant Protein
 		PPK-442
PDK1 Polyclonal Antibody
 		KAP-PK112
PI3-kinase, p85 alpha Monoclonal Antibody (AB6)
 		KAM-PI200E
Rapamycin
 		HPK-109J
S6K/Rsk Substrate
 		SPK-109J
Wortmannin
 		HPK-114J
p70 S6K Activity Kit
 		EKS-470
p70 S6K Polyclonal Antibody
 		KAP-CC035E

Citations
Launch Citation Database

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