IRS-1 (phospho-Tyr612) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
IRS-1 (phospho-Tyr612) Polyclonal Antibody 100 µL  CSA-725E $295.00
Background
The Insulin receptor substrate family, which consists of IRS 1-4, consists of cytoplasmic docking proteins involved in the regulation of metabolism and proliferation by Insulin, IL-4, and other cytokines. Upon binding of insulin to its receptor, the receptor is activated leading to the cross-phosphorylation of tyrosine residues within the cytoplasmic domain. These P-Tyr motifs serve to recruit a variety of Src homology-2 (SH2) domain-containing proteins such as PI3-kinase, Grb-2, SHP-2, Nck and Crk.

Table of Abbreviations

Abbreviated Name
IRS-1 phospho-Tyr612 pAb

Conjugate

Applications
WB

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic phospho-peptide derived from the sequence of human IRS-1; sequence identical with mouse, rat and chicken

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H, (M, R, CH)

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
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 		905-645
Insulin Receptor (phospho-Tyr1322) Monoclonal Antibody (21G12)
 		905-646
Insulin Receptor (phospho-Tyr972) Polyclonal Antibody
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Insulin Receptor Monoclonal Antibody (9H4)
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Insulin Receptor beta Monoclonal Antibody (C18C4)
 		905-683-100

Citations
Launch Citation Database

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