c-Met (phospho-Tyr1230/Tyr1234/Tyr1235) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
c-Met (phospho-Tyr1230/Tyr1234/Tyr1235) Polyclonal Antibody 100 µL  KAP-TK010E $295.00
Background
Binding of Scatter factor (SF)/Hepatocyte growth factor (HGF) to the c-Met receptor tyrosine kinase (RTK) triggers receptor dimerization and phosphorylation on multiple residues within the juxtamembrane, catalytic core and cytoplasmic tail domains, thereby regulating receptor internalization, catalytic activity and multisubstrate docking. Activation of the c-Met receptor results in binding and/or phosphorylation of many intracellular signaling proteins including multiple adaptor proteins (e.g., Grb2, Shc, Cbl, Crk, Cortactin, Paxillin, and GAB1), and a variety of other signal transducers (e.g., PI 3-kinase, FAK, Src, Erk1/2, Jnk, PLC-gamma, and Stat3).

Table of Abbreviations

Abbreviated Name
c-Met phospho-Tyr1230/Tyr1234/Tyr1235 pAb

Conjugate

Applications
ICC, IHC, WB

Isotype
not applicable

Purification
Affinity Purified

Immunogen
Synthetic phospho-peptide derived from the sequence of human c-Met; sequence identical with mouse and rat

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H, M

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
MET/HGFR (phospho-Tyr1234/Tyr1235) Monoclonal Antibody (6AT1877)
 		905-696-100
c-Met Polyclonal Antibody
 		905-076

Citations
Launch Citation Database

Ordering Info
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