EGF Receptor (phospho-Tyr845) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
EGF Receptor (phospho-Tyr845) Polyclonal Antibody 100 µL  CSA-331E $295.00
Background
The epidermal growth factor receptor (EGFR) is a 170-kDa membrane bound receptor consisting of an extracellular ligand-binding domain, a single hydrophobic transmembrane region, and a tyrosine kinase domain-containing cytoplasmic region. Ligand binding induces receptor homo- or heterodimerization, triggering autophosphorylation of cytoplasmic tyrosine residues that provide docking sites for Src homology 2 (SH2) domain-containing signaling molecules. Src-mediated phosphorylation of EGFR at Tyr845 may contribute to EGFR hyperactivity in cancer, while autophosphorylation of EGFR at Tyr1068 and/or Tyr1173 in response to ligand binding is known to recruit cofactors (e.g. SHP1, RasGAP, SOS1, Grb2) that activate pathways associated with cell growth, apoptosis, adhesion, receptor endocytosis, and protein degradation.

Table of Abbreviations

Abbreviated Name
EGF Receptor phospho-Tyr845 pAb

Conjugate

Applications
ICC, WB

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic phospho-peptide derived from the sequence of human EGFR; sequence identical with mouse and rat

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H, (M, R, CH)

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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