NFkappaB p65 (RelA) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
NFkappaB p65 (RelA) Polyclonal Antibody  100 µL KAS-TF110E $255.00  
Background
Nuclear factor kappaB (NFkappaB) was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of the kappa light chain gene in B lymphocytes. NFkappaB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkappaB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection, IkappaB is phosphorylated and degraded by the proteosome. The active NFkappaB heterodimer is translocated into the nucleus and induces gene expression.

Table of Abbreviations

Abbreviated Name
NFkappaB p65 pAb

Conjugate

Applications
WB

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Synthetic peptide derived from the sequence of human p65 NFkB, conjugated to KLH; sequence identical to mouse p65 NFkB

Host
Rabbit

Clone Number
not applicable

PositiveControls
HeLa Cell Lysate, Product#: LYC-HL100

Species Reactivity
H, M, R, B, C, GP, MO, P, RB

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
NFkappaB p65 (RelA) Polyclonal Antibody KAS-TF110E  

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Citations
Launch Citation Database

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