NF kappa B, p65 (RelA) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
NF kappa B, p65 (RelA) Polyclonal Antibody  100 µL KAS-TF110E $255.00  
Background
Nuclear factor kappaB (NFkappaB) was identified as a sequence specific transcriptional activator that binds to the intronic enhancer of the kappa light chain gene in B lymphocytes. NFkappaB is a heterodimer that consists of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA). The p50/p65 heterodimer remains in the cytosol in an inactive form as a complex with its inhibitor, IkappaB. Upon stimulation of cells by a wide variety of stimuli such as lipopolysaccharide (LPS), pro-inflammatory cytokines, and viral infection, IkappaB is phosphorylated and degraded by the proteosome. The active NFkappaB heterodimer is translocated into the nucleus and induces gene expression.

Table of Abbreviations

Applications
WB

Format
Protein A Affinity Purified

HostSpecies
rabbit

Immunogen
Synthetic peptide derived from the sequence of human p65 NF kappa B, conjugated to KLH; sequence identical to mouse p65 NF kappa B

PositiveControls
HeLa Cell Lysate, Product#: LYC-HL100

Species Reactivity
H, M, R, B, C, GP, MO, P, RB

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
NF kappa B, p65 (RelA) Polyclonal Antibody KAS-TF110E  

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Citations
Launch Citation Database

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