IkappaB alpha (phospho-Ser32/Ser36) Monoclonal Antibody (39A1413)

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Description Size Catalog# Price Quantity  
IkappaB alpha (phospho-Ser32/Ser36) Monoclonal Antibody (39A1413) 100 µg  KAM-TF140E $285.00
Background
NFkappaB is silenced in the cytoplasm by the inhibitory protein IkappaBa, which masks nuclear localization signals on NFkappaB. IkappaBa is phosphorylated by the IkappaB kinase (IKK) complex in response to external stimuli such as tumor necrosis factor or other cytokines. IKK specifically phosphorylates IkappaBa on Ser32 and Ser36, leading to ubiquitination of IkappaBa and subsequent degradation by the 26S proteasome. Degradation of IkappaBa exposes the nuclear localization signal of NFkappaB dimers, which then translocate to the nucleus to activate target genes

Table of Abbreviations

Abbreviated Name
IkappaB alpha phospho-Ser32/Ser36 mAb (39A1413)

Conjugate

Applications
IP, WB

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Synthetic phospho-peptide derived from the sequence of human IkB ¦Á

Host
Mouse

Clone Number
39A1413

Product Image(s): click to enlarge

Species Reactivity
H, M

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_KAM-TF140_LOT-07220811
Spec Sheet

Related Products

Product Name Catalog#
IKK epsilon Polyclonal Antibody
 		KAP-TF131E
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 		KAP-TF112
NFkappaB p65 (RelA) Polyclonal Antibody
 		KAS-TF110

Citations
Launch Citation Database

Ordering Info
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