TNF Receptor 1 (TNF-R1) Polyclonal Antibody

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
TNF Receptor 1 (TNF-R1) Polyclonal Antibody	100 痢	CSA-815E	$255.00

Background

Tumor necrosis factor alpha (TNFalpha), also known as cachectin, is a 17.5 kDa 157 amino acid member of the TNF superfamily of cytokines that is a potent lymphoid factor with effects on a wide range of target cells. Active TNFalpha is produced in both soluble and membrane-anchored trimers by macrophages, NK cells, and T- and B-lymphocytes. TNF exerts proinflammatory signals via binding and inducing trimerization of TNF-receptor1 (TNF-R1) expressed on most normal and transformed cells, or to TNF-receptor 2 (TNF-R2), expressed on endothelial and most immune cells. TNF signaling regulates hematopeiesis, differentation, endothelial cell activation, apoptosis, lipid metabolism, tumor progression, and immune suveillance, and dysregulation of TNF or its receptors is implicated in numerous disease states including cancer, osteoporosis, autoimmune disease, diabetes, and atherosclerosis.

Table of Abbreviations

Abbreviated Name
TNF Receptor 1 pAb

Conjugate

Applications
IP, WB

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from the sequence of mouse TNF-R1; sequence identical to rat and human

Host
Rabbit

Clone Number
not applicable

PositiveControls
Mouse Brain Tissue Extract, LYT-MB100 Rat Brain Tissue Extract, LYT-RB100

Species Reactivity
H, M, R, B, C, D, HA, MO, P, RB, S, X, Y

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_CSA-815_LOT-09060703
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
TNF Receptor 1 (TNF-R1) Polyclonal Antibody	CSA-815E

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Citations
Launch Citation Database

Ordering Info
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TNF Receptor 1 (TNF-R1) Polyclonal Antibody