Hsp70B' Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp70B' Polyclonal Antibody 100 µL  SPA-756E $366.00
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Abbreviated Name
Hsp70B' pAb

Conjugate

US Patent
US Patent No. 7,326,574

Applications
IP, WB

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Synthetic peptide derived from sequence near the carboxy-terminus of human Hsp70B', conjugated to KLH

Host
Rabbit

Clone Number
not applicable

Positive Controls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsp70B' Protein, SPP-756

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
HeLa Cell Lysate, Heat Shocked
 		LYC-HL101F
Hsp70B prime ELISA Kit
 		EKS-725
Hsp70B' Monoclonal Antibody (165f)
 		SPA-754
Hsp70B' Monoclonal Antibody (165f)
 		SPA-754E
Hsp70B' Recombinant Human Protein
 		SPP-762E

Citations
Launch Citation Database

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