Akt (phospho-Thr308) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Akt (phospho-Thr308) Polyclonal Antibody 100 µL  KAP-PK007E $325.00
Background
The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified to date (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3beta, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has recently been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.

Table of Abbreviations

Abbreviated Name
Akt phospho-Thr308 pAb

Conjugate

Applications
WB

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic phospho-peptide sequence conserved between mouse and rat Akt1 and Akt2

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H, M

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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