p70 S6K Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
p70 S6K Polyclonal Antibody 100 µg  KAP-CC035E $255.00
Background
p70 S6K is a mitogen stimulated serine/threonine protein kinase that regulates the cell growth and G1 phase cell cycle progression. p70 S6K is activated by serum stimulation and can be inhibited by both wortmannin and rapamycin. Activation of p70 S6K by multi-site phosphorylation requires phosphoinositide 3-kinase (PI3-K)-dependent signal(s) leading to sequential phosphorylation at two key residues: Thr389 and Thr229. Thr229 phosphorylation is mediated by phosphoinositide-dependent kinase 1 (PDK-1), and is dependent upon prior phosphorylation of Thr389. Multiple residues in the p70 S6K pseudosubstrate domain (e.g. Ser411, Thr421, and Ser424) are also subject to activating phosphorylation by upstream kinases.

Table of Abbreviations

Abbreviated Name
p70 S6K pAb

Conjugate

Applications
EIA, IP, WB

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the carboxy-terminus of human p70 S6K, conjugated to KLH

Host
Rabbit

Clone Number
not applicable

PositiveControls
Mouse Brain Tissue Extract, product #LYT-MB100

Species Reactivity
H, M, R, B

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
p70 S6K Activity Kit
 		EKS-470
p70 S6K Recombinant Human Protein
 		PPK-439

Citations
Launch Citation Database

Ordering Info
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