EC SOD Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Background
Harmful reactive oxygen species (ROS) arise from environmental factors as well as from normal aerobic metabolic pathways, including oxidative phosphorylation in mitochondria, antimicrobial responses of polymorphonuclear leukocytes, and the detoxification reactions of the Cytochrome p450 family of monooxygenases. Oxygen is an ideal terminal electron acceptor; the transfer of four electrons to oxygen leads to the formation of two molecules of water, but partial reduction results in the formation of hazardous ROS. In particular, the transfer of a single electron to oxygen forms superoxide anion, whereas the transfer of two electrons yields peroxide. Superoxide Dismutase (SOD) catalyzes the conversion of superoxide anion to hydrogen peroxide and oxygen, and provides the primary cellular defense against the toxicity of superoxide anion. Over expression of SOD protects murine fibrosarcoma cells from apoptosis and promotes cell differentiation. SOD also inhibits adriamycin-induced apoptosis in murine peritoneal macrophages. Finally, mutant variants of SOD have been implicated in the etiology of amyotrophic lateral sclerosis.

Table of Abbreviations

Applications
WB, ICC, IHC

Immunogen
Synthetic peptide derived from the sequence of EC SOD; sequence identical with human, mouse, rat and rabbit

PositiveControls
Rat Brain Tissue Extract, LYT-RB100 Mouse Brain Tissue Extract, LYT-MB100

Species Reactivity
human, mouse, rat

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
EC SOD Polyclonal Antibody SOD-105C  

Related Products

Product Name Catalog#
Cu/Zn SOD Polyclonal Antibody
 		SOD-100
Mn SOD Polyclonal Antibody
 		SOD-110
Superoxide Dismutase Activity Kit
 		900-157

Citations
Launch Citation Database

Ordering Info
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