iNOS Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
iNOS Polyclonal Antibody  50 µg KAS-NO001D $205.00  
iNOS Polyclonal Antibody  200 µg KAS-NO001F $325.00  
Background
The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

Table of Abbreviations

Abbreviated Name
iNOS pAb

Conjugate

Applications
IP, WB

Isotype
not applicable

Purification
Immunoaffinity

Immunogen
Synthetic peptide derived from the sequence of mouse iNOS, conjugated to KLH

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_KAS-NO001_LOT-11030802
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
iNOS Polyclonal Antibody KAS-NO001D  
iNOS Polyclonal Antibody KAS-NO001F  

Related Products

Product Name Catalog#
eNOS Polyclonal Antibody
 		KAP-NO002
uNOS Polyclonal Antibody
 		905-611

Citations
Launch Citation Database

Ordering Info
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