eIF2 alpha (phospho-Ser52) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
eIF2 alpha (phospho-Ser52) Polyclonal Antibody 100 µL   KAP-CP131E $315.00
Background
The eukaryotic translation initiation factors (eIFs) regulate translation at the level of messenger RNA engagement by the ribosome. eIF-2alpha promotes the binding of the initiator tRNA to 40S ribosomal subunits, and is a key signaling component of the unfolded protein response (UPR). eIF-4E recruits mRNAs to the eIF4F complex through binding of their 5' N7-methylguanosine cap. eIF-4E binding proteins-1 and -2 are translational repressors, sequestering eIF-4E in conditions of low cellular demand for translation. Their dissociation from eIF-4E is regulated by phosphorylation in response to growth-promoting stimuli.

Table of Abbreviations

Applications
WB

Species Reactivity
H, M

Conjugate

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic phospho-peptide derived from the sequence of human eIF-2 alpha, sequence conserved with rat, bovine, pig, Drosophila and yeast

Host
Rabbit

Clone Number
not applicable

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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