p38 MAPK (phospho-Thr180/Tyr182) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
p38 MAPK (phospho-Thr180/Tyr182) Polyclonal Antibody 100 µL  KAP-MA022E $325.00
Background
Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.

Table of Abbreviations

Abbreviated Name
p38 MAPK phospho-Thr180/Tyr182 pAb

Conjugate

Applications
IHC, WB

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic phospho-peptide derived from the sequence of human p38; sequence conserved with mouse, rat, canine, monkey and fish (carp)

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
MKK6 Polyclonal Antibody
 		KAP-MA014
p38 (phospho) EIA Kit
 		900-101
p38 MAPK Polyclonal Antibody
 		KAS-MA009
p38 alpha Monoclonal Antibody (13D5)
 		905-663
p38 delta Monoclonal Antibody (5H7)
 		905-664

Citations
Launch Citation Database

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