p38 MAPK Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
p38 MAPK Polyclonal Antibody  100 µL KAS-MA009E $255.00  
p38 MAPK Polyclonal Antibody  25 µL KAS-MA009C $115.00  
Background
Six proteins of the p38 subfamily of MAP kinases have been identified to date, including: p38alpha (SAPK2, CSBP) and its splice variant Mxi; p38beta and beta2; p38gamma (ERK6, SAPK3); and p38delta (SAPK4). p38 MAP kinases contain a conserved TGY motif in their activation loop and are activated in response to cytokines, hormones, GPCRs, and osmotic and heat shock to mediate primarily pro-apoptotic and pro-inflammatory responses. MKK3, MKK4, and MKK6 are known to activate p38 family members with varying specificity. All four p38 isoforms are able to phosphorylate the activating transcription factor 2 (ATF2), and differentially activate numerous substrates including Mnk1/2, Msk, phospholipase A2, and the MAPKAP kinase-2 and -3. Activated MAPKAP kinase-2 subsequently phosphorylates the heat shock protein Hsp27, an F-actin binding protein involved in cytoskeletal maintenance.

Table of Abbreviations

Conjugate

Applications
IHC, IP, WB

Isotype
not applicable

Purification

Immunogen
Synthetic peptide derived from the sequence of human p38, conjugated to KLH; sequence identical to mouse

Host
Rabbit

Clone Number
not applicable

PositiveControls
HeLa Cell Lysate, LYC-HL100 Mouse Brain Tissue Extract, LYT-MB100 Rat Brain Tissue Extract, LYT-RB100

Species Reactivity
H, M, R, B, C, CH, HA, MO, P, RB

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
p38 MAPK Polyclonal Antibody KAS-MA009E  
p38 MAPK Polyclonal Antibody KAS-MA009C  

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Product Name Catalog#
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 		AAP-480E
MKK6 Polyclonal Antibody
 		KAP-MA014
Neurturin Polyclonal Antibody
 		905-295
TRAF1 Monoclonal Antibody (3D4)
 		AAM-421E
p38 MAPK (phospho-Thr180/Tyr182) Polyclonal Antibody
 		KAP-MA022E

Citations
Launch Citation Database

Ordering Info
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