Hsp70/Hsc70 Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp70/Hsc70 Polyclonal Antibody  100 µL SPA-757E $255.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Conjugate

Applications
WB

Isotype
not applicable

Product Image(s): click to enlarge

Purification
Protein A Affinity

Immunogen
Synthetic peptide derived from the sequence of rat Hsp70

Host
Rabbit

Clone Number
not applicable

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsc70 (Hsp73) Protein, SPP-751 Hsp70 (Hsp72) Protein, NSP-555

Species Reactivity
H, M, R, B, C, CH, D, F

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp70/Hsc70 Polyclonal Antibody SPA-757E  

Related Products

Product Name Catalog#
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HeLa Cell Lysate (Heat Shocked)
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Hsc70 (Hsp73) Active Recombinant Protein
 		SPP-751
Hsp70 (Active) Protein - Low Endotoxin
 		ESP-555
Hsp70 (Hsp72) Active Recombinant Protein
 		NSP-555
Hsp70 ELISA Kit
 		EKS-700B
Hsp70/Hsc70 Monoclonal Antibody (N27F34)
 		SPA-820
Hsp70/Hsc70 Monoclonal Antibody (N27F34), AP Conjugate
 		SPA-820AP

Citations
Launch Citation Database

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