Hsc70 (Hsp70) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp70) Polyclonal Antibody   50 µg SPA-757D $130.00  
Hsc70 (Hsp70) Polyclonal Antibody   200 µg SPA-757F $310.00  
Hsc70 (Hsp70) Polyclonal Antibody   1 mg SPA-757J $1,255.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Applications
WB

Species Reactivity
H, M, R, B, C, CH, D, F, GP, HA, MO, P, PL, RB, S, Y

Conjugate

Isotype
not applicable

Clone
not applicable

Purification
Protein A Affinity

Clone Number
not applicable

Immunogen
Synthetic peptide derived from the sequence of rat Hsp70

Product Image(s): click to enlarge

Host
Rabbit

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsc70 (Hsp73) Protein, SPP-751 Hsp70 (Hsp72) Protein, NSP-555

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPA-757_12010817
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp70) Polyclonal Antibody SPA-757D  
Hsc70 (Hsp70) Polyclonal Antibody SPA-757F  
Hsc70 (Hsp70) Polyclonal Antibody SPA-757J  

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Citations
Launch Citation Database

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