Survivin Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Survivin Polyclonal Antibody  100 µg AAP-275E $255.00  
Survivin Polyclonal Antibody  25 µg AAP-275C $115.00  
Background
Survivin is a 16.5 kDa protein and the smallest inhibitor of apoptosis (IAP) so far identified. It is involved in the inhibition of apoptosis and cell division. Survivin expression has been reported at high levels in embryonic tissues, but at low or non-detectable levels in normal tissue. Survivin regulates the G2/M phase of the cell cycle by associating with the mitotic spindle microtubules and directly inhibits Caspase-3 and Caspase-7. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients. Down-regulation or loss of Survivin is thought to inhibit the growth of tumor cells. Further, it has been indicated that Survivin epitopes may serve as important targets for anticancer immunotherapy approaches, and that Survivin is a rational target for apoptosis-based cancer therapy. It has also been proposed that Survivin may be used as a universal tumor antigen for immunotherapy.

Table of Abbreviations

Abbreviated Name
Survivin pAb

Conjugate

Applications
ICC, WB

Isotype
not applicable

Purification
Peptide Affinity

Immunogen
Synthetic peptide derived from sequence near the amino-terminus of human Survivin

Host
Rabbit

Clone Number
not applicable

Species Reactivity
H

For research use only, not for diagnostic or therapeutic use.

Documentation

Product Manual

Product Name Catalog # Manual
Survivin Polyclonal Antibody AAP-275E   Spec Sheet   
Survivin Polyclonal Antibody AAP-275C   Spec Sheet   

Related Products

Product Name Catalog#
Survivin (human total) EIA Kit
 		900-111
Survivin Monoclonal Antibody (32.1)
 		905-627
Survivin Monoclonal Antibody (60.11)
 		905-632

Citations
Launch Citation Database

Ordering Info
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