Hsp90 beta Monoclonal Antibody (K3701)

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
Hsp90 beta Monoclonal Antibody (K3701)	100 痢	SPA-843E	$230.00
Hsp90 beta Monoclonal Antibody (K3701)	50 痢	SPA-843D	$160.00
Hsp90 beta Monoclonal Antibody (K3701)	200 痢	SPA-843F	$340.00

Background

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Table of Abbreviations

Conjugate

Applications
Flow, WB

Isotype
IgM

Purification
Ammonium sulfate precipitation

Immunogen
Recombinant human Hsp90 汕 protein

Host
Mouse

Clone Number
K3701

Product Image(s): click to enlarge

PositiveControls
HeLa Cell Lysate, LYC-HL100 Hsp90 Protein, SPP-770

Species Reactivity
H, M, R, B, C, GP, HA, P, RB, S

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
Hsp90 beta Monoclonal Antibody (K3701)	SPA-843E
Hsp90 beta Monoclonal Antibody (K3701)	SPA-843D
Hsp90 beta Monoclonal Antibody (K3701)	SPA-843F

Related Products

Product Name	Catalog#
Hsp90 Beta Recombinant Protein	SPP-777
HeLa Cell Lysate	LYC-HL100F
Hsp90 Monoclonal Antibody (AC88)	SPA-830
Hsp90 Monoclonal Antibody (16F1)	SPA-835
Hsp90 Native Protein	SPP-770
Hsp90 beta Monoclonal Antibody (K3705)	SPA-842

Citations
Launch Citation Database

Ordering Info
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Hsp90 beta Monoclonal Antibody (K3701)