Apaf-1 Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Apaf-1 Polyclonal Antibody  100 µg AAP-300E $295.00  
Apaf-1 Polyclonal Antibody  25 µg AAP-300C $115.00  
Background
Apaf-1 (Apoptosis protease-activating factor 1), a mammalian protein homologous to C. elegans CED-4, is an essential adaptor molecule and a key linker of the mitochondrial apoptotic pathway. Apaf-1 binds to Cytochrome c (Apaf-2) leading to the formation of a large multimeric complex. This complex recruits (through CARD) Procaspase-9 and once activated, caspase-9 (Apaf-3) dissociates. Activated caspase-9 in turn cleaves and activates caspase-3, one of the proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf-1 can also associate with caspase-4, caspase-8 and Diva. Apaf-1 is ubiquitously expressed in human tissues.

Table of Abbreviations

Applications
WB

Format
Purified (Immunoaffinity)

HostSpecies
rabbit

Immunogen
Synthetic peptide derived from the sequence of human Apaf-1, conjugated to KLH

PositiveControls
HeLa Cell Lysate, LYC-HL100 Mouse Brain Tissue Extract, LYT-MB100 Rat Brain Tissue Extract, LYT-RB100

Species Reactivity
H, M, R, CH

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
Apaf-1 Polyclonal Antibody AAP-300E  
Apaf-1 Polyclonal Antibody AAP-300C  

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Citations
Launch Citation Database

Ordering Info
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