Hsc70 (plant ER, BiP) Monoclonal Antibody (1D9)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (plant ER, BiP) Monoclonal Antibody (1D9)  100 µg SPA-818E $295.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Applications
IP, WB

Format
Purified (Protein G)

CloneNumber
1D9

HostSpecies
mouse

Immunogen
Recombinant spinach Hsc70 (Hsp73) protein

Species Reactivity
PL

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
Hsc70 (plant ER, BiP) Monoclonal Antibody (1D9) SPA-818E  

Related Products

Product Name Catalog#
Grp78 (BiP) Polyclonal Antibody
 		SPA-826

Citations
Launch Citation Database

Ordering Info
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