DNA-topoisomerase II alpha/beta Monoclonal Antibody (AK5)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
DNA-topoisomerase II alpha/beta Monoclonal Antibody (AK5) 100 µg  KAM-CC215E $295.00
Background
DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.

Table of Abbreviations

Abbreviated Name
DNA-topoisomerase II alpha/beta mAb (AK5)

Conjugate

Applications
WB

Isotype
IgG1

Purification
Protein A Affinity

Immunogen
Recombinant human DNA-Topoisomerase II (amino-terminal fragment)

Host
Mouse

Clone Number
AK5

PositiveControls
HeLa Cell Lysate, LYC-HL100

Species Reactivity
H, M, R, HA

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
Nucleolin Monoclonal Antibody (4E2)
 		KAM-CP100E

Citations
Launch Citation Database

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