HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )

Brand: Stressgen

Print Page

Description	Size	Catalog#	Price	Quantity
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	25 痢	OSA-111C	$175.00
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	1 mg	OSA-111J	$2,400.00
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	50 痢	OSA-111D	$190.00
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	200 痢	OSA-111F	$390.00

Background

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Table of Abbreviations

Species Reactivity
H, M, R, C, GP, GR, HA, MO, P, RB

CloneNumber
HO-1-2

Product Image(s): click to enlarge

HostSpecies
mouse

PositiveControls
HO-1 (Hsp32) Protein, SPP-730

Immunogen
Native rat HO-1 protein

Applications
Flow, IHC, WB

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	OSA-111C
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	OSA-111J
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	OSA-111D
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )	OSA-111F

Related Products

Product Name	Catalog#
Goat anti-Mouse IgG(Fab) Polyclonal Antibody, HRP Conjugate	SAB-100J
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 ), FITC Conjugate	OSA-111FI
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), PE Conjugate	OSA-111PE
HO-1 (Hsp32) Polyclonal Antibody	SPA-895
HO-1 (Hsp32) Polyclonal Antibody	SPA-894
HO-1 (Hsp32) Polyclonal Antibody	SPA-896
HO-1 (Hsp32) Recombinant Protein	SPP-732
HO-1 (Hsp32) Recombinant Protein	SPP-730
HO-1 (Human) ELISA Kit	EKS-800
HO-1 (Rat) ELISA Kit	EKS-810A
Heme Oxygenase-1 Monoclonal Antibody (HO-1-2), DyLight(TM) 488 Conjugate	OSA-111-488
Mouse Liver Microsome Extract	LYT-MM100F

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134

Browse by

HO-1 (Hsp32) Monoclonal Antibody (HO-1-2 )