nNOS Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
nNOS Polyclonal Antibody  100 µg KAP-NO003E $345.00  
Background
The diffusible free radical gas nitric oxide (NO) affects a variety of physiological functions, and is a key regulator of the cardiovascular, nervous, and immune systems. NO is synthesized in many tissues from L-arginine, oxygen, and NADPH by three known isoforms of a heme-containing flavoprotein termed NO synthase (nNOS/NOS-I, iNOS/NOS-II, and eNOS/NOS-III). nNOS is a constitutively expressed neuronal NOS isoform that exits in its latent form until it is activated by the binding of calmodulin follo wing elevation of intracellular calcium levels. The C-terminus of nNOS contains a conserved serine residue, Ser1417, analogous to Ser1177 of the constitutively expressed endothelial NOS isoform (eNOS). Phosphorylation of Ser1417 is believed to regulate nNOS activation, particularly in glucose-sensing neurons, where inhibition of AMPK pathways by glucose and leptin serve to suppress nNOS activity, whereas activation of AMPK by insulin leads to nNOS activation.

Table of Abbreviations

Applications
EIA, ICC, WB

Format
Purified Affinity

HostSpecies
rabbit

Immunogen
Synthetic peptide derived from the sequence of human nNOS, conjugated to KLH; sequence identical to human, mouse and bovine

Species Reactivity
H, M, R

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Product Manual

Product Name Catalog # Manual
nNOS Polyclonal Antibody KAP-NO003E  

Related Products

Product Name Catalog#
Nitric Oxide (regular) Detection Kit
 		917-010
Nitric Oxide (total) Detection Kit
 		917-020
eNOS Polyclonal Antibody
 		KAP-NO002
eNOS rabbit polyclonal antibody
 		905-386
uNOS Polyclonal Antibody
 		905-611

Citations
Launch Citation Database

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