HO-1 (Hsp32) Polyclonal Antibody

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
HO-1 (Hsp32) Polyclonal Antibody	50 痢	OSA-150D	$125.00
HO-1 (Hsp32) Polyclonal Antibody	100 痢	OSA-150E	$195.00
HO-1 (Hsp32) Polyclonal Antibody	200 痢	OSA-150F	$305.00

Background

Heme Oxygenase-1 (HO-1) also known as Hsp32, is the inducible isoform of heme oxygenase that catalyzes the NADPH, oxygen, and cytochrome P450 reductase dependent oxidation of heme to carbon monoxide, ferrous iron and biliverdin which is rapidly reduced to bilirubin. These products of the HO reaction have important physiological effects: carbon monoxide is a potent vasodilator and has been implicated to be a physiological regulator of cGMP and vascular tone; biliverdin and its product bilirubin are potent antioxidants; "free" iron increases oxidative stress and regulates the expression of many mRNAs (e.g., DCT-1, ferritin and transferring receptor) by affecting the conformation of iron regulatory protein (IRP)-1 and its binding to iron regulatory elements (IREs) in the 5'- or 3'- UTRs of the mRNAs. To date, three identified heme oxygenase isoforms are part of the HO system that catalyze heme into biliverdin and carbon monoxide. These are inducible HO-1 or Hsp32, constitutive HO-2 that is abundant in the brain and testis, and HO-3 which is related to HO-2 but is the product of a different gene. The HO system is the rate-limiting step in heme degradation and HO activity decreases the levels of heme which is a well known potent catalyst of lipid peroxidation and oxygen radical formation.

Table of Abbreviations

Abbreviated Name
HO-1 pAb

Conjugate

Applications
WB

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Native rat liver HO-1 (Hsp32) protein

Host
Rabbit

Clone Number
not applicable

Product Image(s): click to enlarge

PositiveControls
Rat HO-1 (Hsp32) Protein, SPP-730Human HO-1 (Hsp32) Protein, SPP-732

Species Reactivity
Rat HO-1, rat liver microsomes and mouse liver microsomes; human liver microsomes (weak)

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
HO-1 (Hsp32) Polyclonal Antibody	OSA-150D
HO-1 (Hsp32) Polyclonal Antibody	OSA-150E
HO-1 (Hsp32) Polyclonal Antibody	OSA-150F

Related Products

Product Name	Catalog#
Goat anti-Rabbit IgG Polyclonal Antibody, AP	SAB-301J
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), DyLight 488	OSA-111-488
HO-1 (Hsp32) Monoclonal Antibody (HO-1-2), DyLight 488	OSA-111-488
HO-1 (Hsp32) Polyclonal Antibody	SPA-895
HO-1 (Hsp32) Polyclonal Antibody	SPA-894
HO-1 (Hsp32) Recombinant Human Protein	SPP-732
HO-1 (Rat) ELISA Kit	EKS-810A
Human Liver Microsome Extract	LYT-HM100F
Mouse Liver Microsome Extract	LYT-MM100F
Rat Liver Microsome Extract	LYT-RM100F

Citations
Launch Citation Database

Ordering Info
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HO-1 (Hsp32) Polyclonal Antibody