Hsp90 Monoclonal Antibody (2D12)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsp90 Monoclonal Antibody (2D12)  50 µL SPA-845D $125.00  
Hsp90 Monoclonal Antibody (2D12)  100 µL SPA-845E $225.00  
Background
The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Table of Abbreviations

Abbreviated Name
Hsp90 mAb (2D12)

Conjugate

Applications
WB

Isotype
IgM

Purification
Ammonium Sulfate Precipitation

Immunogen
Native mouse Hsp90 protein

Host
Rat

Clone Number
2D12

Product Image(s): click to enlarge

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsp90 Protein, SPP-770 Hsp90 Alpha Protein, SPP-776

Species Reactivity
H, MO, M, R, BE, B, C, CH, F, GP, HA, RB, S

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsp90 Monoclonal Antibody (2D12) SPA-845D  
Hsp90 Monoclonal Antibody (2D12) SPA-845E  

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Citations
Launch Citation Database

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