Hsc70 (Hsp73) Rat Monoclonal Antibody (1B5)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp73) Rat Monoclonal Antibody (1B5)  200 µg SPA-815F $340.00  
Hsc70 (Hsp73) Rat Monoclonal Antibody (1B5)  50 µg SPA-815D $160.00  
Hsc70 (Hsp73) Monoclonal Antibody (1B5)  1 mg SPA-815J $1,400.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Abbreviated Name
Hsc70 Rat mAb (1B5)

Conjugate

Applications
WB

Isotype
IgG2a

Purification
Protein G Affinity

Immunogen
Native hamster Hsc70 (Hsp73) protein

Host
Rat

Species Reactivity
H, M, R, B, C, CH, GP, HA, MO, P, RB, S

Clone Number
1B5

Product Image(s): click to enlarge

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsc70 (Hsp73) Protein, SPP-751

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp73) Rat Monoclonal Antibody (1B5) SPA-815F   Spec Sheet   
Hsc70 (Hsp73) Rat Monoclonal Antibody (1B5) SPA-815D   Spec Sheet   
Hsc70 (Hsp73) Monoclonal Antibody (1B5) SPA-815J  

Related Products

Product Name Catalog#
HeLa Cell Lysate
 		LYC-HL100F
Hsc70 (Hsp73) (ATPase Fragment) Recombinant Bovine Protein
 		SPP-752
Hsc70 (Hsp73) Polyclonal Antibody
 		SPA-819
Hsc70 (Hsp73) Rat Monoclonal Antibody (1B5), DyLight 488
 		SPA-815-488
Hsc70 (Hsp73) Rat Monoclonal Antibody (1B5), PE
 		SPA-815PE
Hsc70 (Hsp73) Recombinant Bovine Protein
 		SPP-751
Hsp70 (Anti-Human IgG/A/M) ELISA
 		EKS-750
Hsp70 ELISA Kit
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Rabbit anti-Rat IgG Polyclonal Antibody, HRP
 		SAB-200J

Citations
Launch Citation Database

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