Hsc70 (Hsp73) Monoclonal Antibody (1B5)

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
Hsc70 (Hsp73) Monoclonal Antibody (1B5)	200 痢	SPA-815F	$340.00
Hsc70 (Hsp73) Monoclonal Antibody (1B5)	50 痢	SPA-815D	$160.00
Hsc70 (Hsp73) Monoclonal Antibody (1B5)	1 mg	SPA-815J	$1,400.00

Background

The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Applications
WB

Purification
Protein G Affinity

Species Reactivity
H, M, R, B, C, CH, GP, HA, MO, P, RB, S

CloneNumber
1B5

Product Image(s): click to enlarge

HostSpecies
rat

Immunogen
Native hamster Hsc70 (Hsp73) protein

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsc70 (Hsp73) Protein, SPP-751

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS

Product Manual

Product Name	Catalog #	Manual
Hsc70 (Hsp73) Monoclonal Antibody (1B5)	SPA-815F	TechSpec
Hsc70 (Hsp73) Monoclonal Antibody (1B5)	SPA-815D	TechSpec
Hsc70 (Hsp73) Monoclonal Antibody (1B5)	SPA-815J

Related Products

Product Name	Catalog#
HeLa Cell Lysate	LYC-HL100F
Hsc70 (Hsp73) Active Recombinant Protein	SPP-751
Hsc70 (Hsp73) Monoclonal Antibody (1B5), DyLight(TM) 488 Conjugate	SPA-815-488
Hsc70 (Hsp73) Monoclonal Antibody (1B5), R-Phycoerythrin Conjugate	SPA-815PE
Hsc70 (Hsp73) Polyclonal Antibody	SPA-819
Hsc70 (Hsp73) Recombinant Protein (ATPase fragment)	SPP-752
Hsp70 (Anti-Human IgG/A/M) ELISA	EKS-750
Hsp70 ELISA Kit	EKS-700B
Rabbit anti-Rat IgG Polyclonal Antibody, HRP Conjugate	SAB-200J

Citations
Launch Citation Database

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Hsc70 (Hsp73) Monoclonal Antibody (1B5)