Hsp90 Monoclonal Antibody (AC88)

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
Hsp90 Monoclonal Antibody (AC88)	200 痢	SPA-830F	$355.00
Hsp90 Monoclonal Antibody (AC88)	50 痢	SPA-830D	$165.00

Background

The Hsp90 family of heat shock proteins represents one of the most abundantly expressed and highly conserved families of cellular chaperones whose expression can be upregulated under conditions of cellular stress, and includes cytoplasmic (Hsp90-alpha/beta), ER (grp94), and mitochondrial (TRAP1) localized members. Structurally, Hsp90 is characterized by an N-terminal ATP-binding domain, a medial substrate-binding domain, and a C-terminal dimerization motif. Hsp90 dimers function in cooperation with cochaperones (e.g. Hsp40, Hsp70, Hop, p23) to stabilize a multitude of client protein substrates, including steroid hormone receptors, protein kinases, and transcription factors. The essential binding and hydrolysis of ATP by Hsp90 is inhibited by ansamycin drugs (e.g. geldanamycin, 17-AAG) which occupy the N-terminal Hsp90 nucleotide-binding pocket. Many Hsp90 client proteins such as erbB2/Her-2, c-raf, bcr-abl, p53, and hTERT, are members of well characterized oncogenic pathways, making Hsp90 inhibitors useful anticancer agents.

Table of Abbreviations

Conjugate

Applications
Flow, ICC, IHC, IP, WB

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Achlya ambisexualis (water mold) Hsp90 protein

Host
Mouse

Clone Number
AC88

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsp90 Protein, SPP-770 Hsp90 Alpha Protein, SPP-776

Species Reactivity
H, M, R, B, C, CE, CH, F

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
Hsp90 Monoclonal Antibody (AC88)	SPA-830F
Hsp90 Monoclonal Antibody (AC88)	SPA-830D

Related Products

Product Name	Catalog#
Goat anti-Mouse IgG(Fab) Polyclonal Antibody, HRP Conjugate	SAB-100J
Grp94 Polyclonal Antibody	SPA-851
HeLa Cell Lysate (Heat Shocked)	LYC-HL101F
Hsp90 Monoclonal Antibody (AC88), DyLight(TM) 488 Conjugate	SPA-830-488
Hsp90 Monoclonal Antibody (AC88), R-Phycoerythrin Conjugate	SPA-830PE
Hsp90 Native Protein	SPP-770
Hsp90 alpha ELISA Kit	EKS-895
Hsp90 alpha Recombinant Protein	SPP-776
Hsp90 beta Monoclonal Antibody (K3701)	SPA-843

Citations
Launch Citation Database

Ordering Info
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Hsp90 Monoclonal Antibody (AC88)