Hsc70 (Hsp70) Monoclonal Antibody (BB70)

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp70) Monoclonal Antibody (BB70)  200 µg SPA-822F $340.00  
Hsc70 (Hsp70) Monoclonal Antibody (BB70)  50 µg SPA-822D $160.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Abbreviated Name
Hsc70 mAb (BB70)

Conjugate

Applications
WB

Isotype
IgG2a

Purification
Protein G Affinity

Immunogen
Chicken Hsp70/Hsp90 complex

Product Image(s): click to enlarge

Host
Mouse

Clone Number
BB70

PositiveControls
HeLa Cell Lysate (Heat Shocked), LYC-HL101 Hsp70 (Hsp72) Protein, NSP-555 Hsc70 (Hsp73) Protein, SPP-751

Species Reactivity
H, M, R, RB

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp70) Monoclonal Antibody (BB70) SPA-822F  
Hsc70 (Hsp70) Monoclonal Antibody (BB70) SPA-822D  

Related Products

Product Name Catalog#
3T3 Cell Lysate
 		LYC-3T100F
Goat anti-Mouse IgG Polyclonal Antibody, AP
 		SAB-101J
HeLa Cell Lysate, Heat Shocked
 		LYC-HL101F
Hsc70 (Hsp73) Recombinant Bovine Protein
 		SPP-751
Hsp70 (Hsp72) Recombinant Human Protein
 		NSP-555
PC-12 Cell Lysate
 		LYC-PC100F

Citations
Launch Citation Database

Ordering Info
Click here to learn more about online ordering
 Order by phone: 734-668-6113 or 877-423-4548
Order by e-mail: orders@assaydesigns.com
Order by fax: 734-669-0134