Hsp27 Monoclonal Antibody (G3.1)

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
Hsp27 Monoclonal Antibody (G3.1)	50 痢	SPA-800D	$160.00
Hsp27 Monoclonal Antibody (G3.1)	200 痢	SPA-800F	$340.00
Hsp27 Monoclonal Antibody (G3.1)	1 mg	SPA-800J	$1,400.00

Background

Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes alphaB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-alpha, p70 S6K, PKD I, and PKC-delta. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

Table of Abbreviations

Abbreviated Name
Hsp27 mAb (G3.1)

Conjugate

Applications
WB

Isotype
IgG1

Purification
Protein G Affinity

Species Reactivity
H, MO

Immunogen
Native human Hsp27 protein

Product Image(s): click to enlarge

Host
Mouse

Clone Number
G3.1

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
Hsp27 Monoclonal Antibody (G3.1)	SPA-800D
Hsp27 Monoclonal Antibody (G3.1)	SPA-800F
Hsp27 Monoclonal Antibody (G3.1)	SPA-800J

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Hsp27 (phospho-Ser15) EIA Kit	900-170
Hsp27 (phospho-Ser78) EIA Kit	900-165
Hsp27 (phospho-Ser82) Polyclonal Antibody	SPA-524
Hsp27 ELISA Kit	EKS-500
Hsp27 Monoclonal Antibody (G3.1), Biotin	SPA-800B
Hsp27 Monoclonal Antibody (G3.1), DyLight 488	SPA-800-488
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Citations
Launch Citation Database

Ordering Info
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Hsp27 Monoclonal Antibody (G3.1)