Hsc70 (Hsp73) Polyclonal Antibody

Brand: Stressgen Print Page
Description Size Catalog# Price Quantity  
Hsc70 (Hsp73) Polyclonal Antibody  200 µg SPA-816F $325.00  
Hsc70 (Hsp73) Polyclonal Antibody  50 µg SPA-816D $125.00  
Hsc70 (Hsp73) Polyclonal Antibody  1 mg SPA-816J $1,350.00  
Background
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.

Table of Abbreviations

Abbreviated Name
Hsc70 pAb

Conjugate

Applications
WB

Isotype
not applicable

Purification
Protein A Affinity

Immunogen
Synthetic peptide derived from the sequence of human Hsc70 (Hsp73); sequence identical to rat, mouse, hamster & bovine

Host
Rabbit

Clone Number
not applicable

PositiveControls
HeLa Cell Lysate, LYC-HL100 Hsc70 (Hsp73) Protein, SPP-751

Species Reactivity
H, M, R, B, C, GP, HA, MO, P, RB, S

For research use only, not for diagnostic or therapeutic use.

Documentation
MSDS
Spec Sheet

Product Manual

Product Name Catalog # Manual
Hsc70 (Hsp73) Polyclonal Antibody SPA-816F  
Hsc70 (Hsp73) Polyclonal Antibody SPA-816D  
Hsc70 (Hsp73) Polyclonal Antibody SPA-816J  

Related Products

Product Name Catalog#
Bag-1 Polyclonal Antibody
 		905-735-100
Hsc70 (Hsp73) Polyclonal Antibody
 		SPA-819
Hsc70 (Hsp73) Recombinant Bovine Protein
 		SPP-751

Citations
Launch Citation Database

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