PGE2 Monoclonal Antibody (BG8)

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Description Size Catalog# Price Quantity  
PGE2 Monoclonal Antibody (BG8) 100 µL  905-628 $625.00
Background
Prostaglandin E2 (PGE2) is an extensively studied prostaglandin owing to its predominance in inflammation, cancer, atherosclerosis, autoimmune disease, and sepsis. Oxidation of arachidonic acid by prostaglandin synthases (COX-1 and COX-2) produces prostaglandin H2 (PGH2), which is further metabolized by PGE synthases into its major product, PGE2. PGE2 mediates autocrine and paracrine signaling by binding to G-protein coupled receptors (EP1, EP2, EP3, EP4) on the cell surface, functioning to modulate phospholipase C and adenylate cyclase activity. PGE2 has been of great interest as a therapeutic target, either by modulation of its synthesis by COX inhibitors (NSAIDS) or by modulation of its receptors by downregulation or binding antagonists. PGE2 production in a variety of tissues has been shown to modulate numerous physiological processes including natriuresis in the kidney, smooth muscle elasticity in the vasculature, and the inflammatory response to damaged tissues by monocytes and macrophages.

Table of Abbreviations

Abbreviated Name
PGE2 mAb (BG8)

Conjugate

Species Reactivity
Species Independent

Applications
EIA

Isotype
not available

Purification
Ascites

Immunogen
PGE2

Host
Mouse

Clone Number
BG8

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

Related Products

Product Name Catalog#
PGE2 CLIA Kit
 		910-001
PGE2 EIA Kit
 		900-001
PGE2 EIA Kit
 		901-001
PGE2 FPIA Kit
 		920-001
PGE2 High Sensitivity EIA Kit
 		930-001
PGE2 High Sensitivity EIA Kit
 		931-001

Citations
Launch Citation Database

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