Serotonin Monoclonal Antibody (SPM146)

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Description Size Catalog# Price Quantity  
Serotonin Monoclonal Antibody (SPM146) 1.0 mL  905-548 $195.00
Background
Serotonin (5-hydroxytryptamine, 5-HT) is a monoamine found in the central nervous system, gastrointestinal tract, and blood with broad physiological functions in neurotransmission, gastric motility, hemostasis, and cardiovascular integrity. Seven subclasses (5-HT 1-7) of serotonin receptors have been identified, a majority of which are members of the seven transmembrane domain-containing GPCR family, and are the target of several anti-depressant drugs. The 5-HT1 subclass consists of five highly homologous receptors that couple via G(i/o) alpha subunits to inhibit adenylyl cyclase activity. 5-HT1A expression in mammals is strongest in CNS limbic pathways that control emotion, including tissue of the hippocampus, dorsal raphé, and septum.

Table of Abbreviations

Applications
IHC

Conjugate

Species Reactivity
H

Abbreviated Name
Serotonin MAb (SPM146)

Isotype
IgG1

Purification

Immunogen
5-Hydroxytryptamine hydrochloride (3-(2-aminoethyl)-5-hydroxyindole serotonin).

Host
Mouse

Clone Number
SPM146

For research use only, not for diagnostic or therapeutic use.

Documentation
Spec Sheet

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Citations
Launch Citation Database

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