Grp75 (Mortalin) Polyclonal Antibody

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
Grp75 (Mortalin) Polyclonal Antibody	50 痢	SPS-827D	$130.00
Grp75 (Mortalin) Polyclonal Antibody	200 痢	SPS-827F	$310.00

Background

Cells from various organisms increase expression of a class of proteins referred to as heat shock or stress proteins in response to adverse changes in their environment. The members of one class of stress proteins, the Hsp70 family, all bind ATP in vitro, but exist within different intracellular compartments. Members include constitutive form Hsc70 within the cytosol/nucleus; inducible form Hsp70 within the cytosol/nucleus/nucleolus; the constitutive glucose-regulated 78 kDa (or BiP) protein within the lumen of the endoplasmic reticulum; and the constitutive glucose-regulated 75 kDa protein within the mitochondrial matrix. Members of the Hsp70 family appear to function as molecular chaperones, assisting in the folding of other proteins in various intracellular compartments. Grp75 resides in the mitochondrial matrix where it collaborates with Hsp60 in the re-folding of proteins translocated into this organelle. Like its E. coli homolog DnaK, Grp75 possesses a cation-dependent ATPase activity considered central to its function as a chaperone.

Table of Abbreviations

Applications
WB

Species Reactivity
H, M, R, B, C, D, GP, HA, MU, RB, X

Purification
Protein A Affinity

Immunogen
Synthetic peptide derived from the C-terminus of human Grp75 (Mortalin) coupled to KLH.

Host
Rabbit

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPS-827_04010911
MSDS
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
Grp75 (Mortalin) Polyclonal Antibody	SPS-827D
Grp75 (Mortalin) Polyclonal Antibody	SPS-827F

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Citations
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Grp75 (Mortalin) Polyclonal Antibody