12-HETE Polyclonal Antibody

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Description Size Catalog# Price Quantity  
12-HETE Polyclonal Antibody lyoph  905-032 $115.00
Background
HETEs are byproducts generated by the metabolism of arachidonic acid by lipoxygenases. 12(S)-HETE is the stereospecific hydroxy product from the reduction of 12(S)-hydroperoxy tetraenoic eicosatetraenoic acid [12(S)-HpETE], which itself is a 12-lipoxygenase metabolite of arachidonic acid. 12(S)-HETE is chemotactic and chemokinetic for polymorphonuclear leukocytes and vascular smooth muscle cells. It also acts as a second messenger in angiotensin-II induced aldosterone production. 15-hydroxyeicosatetraenoic acid [15(S)-HETE] is the major hydroxy derivative of arachidonic acid when acted upon by 15-lipoxygenase. It is also the primary monohydroxy acid synthesized by the lipoxygenase activity of Cyclooxygenase-1 upon linoleic acid. 15(S)-HETE acts as a paracrine regulator of smooth muscle and lung neutrophil recruitment, and elevated levels of 15(S)-HETE are associated with asthma, rhinitis, chronic paranasal sinusitis and rheumatoid arthritis.

Table of Abbreviations

Conjugate

Species Reactivity
Species Independent

Applications
EIA

Isotype
not applicable

Purification

Immunogen
(see spec sheet)

Host
Rabbit

Clone Number
not applicable

Cross Reactivities
12-HETE 100%
15-HETE 0.30%
5-HETE 0.20%
0.10%: 8,15-DiHETE, 5,15-DiHETE, PGE2, PGF2a, PGD2, 6-keto-PGF1a, TXB2, Arachidonic acid

For research use only, not for diagnostic or therapeutic use.

Documentation
TechSpec

Related Products

Product Name Catalog#
12(S)-HETE EIA Kit
 		900-050
12(S)-HETE EIA Kit
 		901-050

Citations
Launch Citation Database

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