Hsp70 (Hsp72) Monoclonal Antibody (N6F3-6.140)

Brand: Stressgen

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Description	Size	Catalog#	Price	Quantity
Hsp70 (Hsp72) Monoclonal Antibody (N6F3-6.140)	50 痢	SPA-8136D	$165.00
Hsp70 (Hsp72) Monoclonal Antibody (N6F3-6.140)	200 痢	SPA-8136F	$345.00

Background

The 70 kDa heat shock protein Hsp70 belongs to the Hsp70 family of highly-related protein isoforms ranging in size from 66 kDa to 78 kDa. Hsc70 shares close biochemical and biological ties to Hsp70, and also belongs to the Hsp70 family. These proteins include cognate members found within major intracellular compartments and highly inducible isoforms predominantly cytoplasmic or nuclear in distribution. Members of the Hsp70 family function as molecular chaperones involved in such cellular functions as protein folding, transport, maturation and degradation, operating in an ATP-dependent manner. The molecular chaperones of the Hsp70 family recognize and bind to nascent polypeptide chains or partially folded intermediates of proteins, preventing their aggregation and misfolding, and the binding of ATP triggers a critical conformational change leading to the release of the bound substrate protein. Data demonstrates that with a ubiquitin-like domain at its amino terminus and its association with the 26S proteosome in HeLa cells, Bag-1 modulates the chaperone activity of Hsc70 and Hsp70. These findings reveal Bag-1's role as a physical link between the Hsc70/Hsp70 chaperone system and the proteasome. Experimental data also shows that the ATPase domain and the substrate binding domain of Hsp70 (or Hsc70) cooperate to form a co-chaperone-chaperone complex with the synaptic vesicle cysteine string protein (csp), essential for normal neurotransmitter release.

Table of Abbreviations

Applications
WB

Species Reactivity
H

Isotype
IgG1

Purification
Protein G Affinity

Immunogen
Native human Hsp70 protein

Host
Mouse

Clone Number
N6F3-6.140

For research use only, not for diagnostic or therapeutic use.

Documentation
CofA_SPA-8136_LOT_04010921
MSDS
Spec Sheet

Product Manual

Product Name	Catalog #	Manual
Hsp70 (Hsp72) Monoclonal Antibody (N6F3-6.140)	SPA-8136D	CofA_SPA-8136_LOT_04010921 MSDS Spec Sheet
Hsp70 (Hsp72) Monoclonal Antibody (N6F3-6.140)	SPA-8136F

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Citations
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Hsp70 (Hsp72) Monoclonal Antibody (N6F3-6.140)